(Close): Wall Street gave up an early rally and ended lower after downbeat consumer and industrial production data.
The Dow Jones closed down 105.9 points at 15,070, while the broad-based S&P 500 lost 9.63 points at 1,626.7.
Shares in Myriad Genetics sank 13.8% after a Supreme Court ruling over its patents.
Groupon shares jumped 11.5% after Deutsche Bank gave the online coupon company an upgrade.
Financials were hit, with American Express down 3%, Citigroup 2.1% lower, and JPMorgan Chase 1.9% down.
