Jamaican international goalkeeper Nicole McClure joined the Swifts this month
Holders Linfield Ladies were knocked out of the NIFL League Cup as they suffered a 2-1 defeat at home to Sion Swifts Ladies.
Chloe McGlade and Aimee Mackin netted for the Swifts to send them through to the semi-finals of the competition.
Megan Bell scored a late consolation for Linfield, who were also knocked out of the County Antrim Cup earlier this month by Cliftonville.
Glentoran Women reached the last four with an easy 5-0 win over Comber Rec.
The Glens will play either Derry City or Crusaders Strikers, whose quarter-final tie will be played on 6 May, in the League Cup semi-finals.
Sion Swifts will play Cliftonville Ladies in their last-four tie, with the north Belfast club having received a bye through to this stage of the competition.
In Monday night's quarter-final at Midgely Park, McGlade opened the scoring for the Strabane outfit against the Blues after a goalmouth scramble in the third minute.
Mackin doubled the lead midway through the first half before a string of excellent saves from Jamaican international goalkeeper Nicole McClure maintained the visitors' lead, with Bell scoring for the hosts in injury time.
Rachel Rogan hit a double for the Glens, who lost in the semi-finals last season, in their win over newly-promoted Comber Rec.
Nadene Caldwell opened the scoring for Diarmuid O'Carroll's side, with Sarah Gamble and Olivia Marshall also on target.
